Multiple host immune and barrier function pathways

Multiple host immune and barrier function pathways refers to a broad therapeutic strategy rather than a single molecular target. This approach focuses on the integrated regulation of the body's immune system and the structural integrity of epithelial barriers, particularly in the gastrointestinal tract (Martini et al., 2017, Cell Host & Microbe). It is a concept central to the development of live biotherapeutic products (LBPs), such as EDP1815, which aim to treat systemic inflammatory diseases by acting on the gut-immune axis (Evelo Biosciences, 2021). By influencing these pathways, drugs can modulate the production of various cytokines and enhance the expression of tight junction proteins, thereby reducing systemic inflammation and preventing the translocation of pro-inflammatory triggers (Round & Mazmanian, 2009, Nature Reviews Immunology). Because this target encompasses a wide array of receptors, signaling molecules, and cellular processes, it is classified as a systems-level or pathway-level intervention rather than a specific protein target. This multi-pathway modulation is intended to provide a safer, non-immunosuppressive alternative to traditional biologics for conditions like psoriasis and atopic dermatitis.

Other names

Host immune and barrier pathwaysGut-immune axis modulationEpithelial barrier integritySystemic immune and barrier function

Modulation of systemic immune responses and enhancement of epithelial barrier integrity through interactions with the gut-associated lymphoid tissue (GALT) and enteric signaling pathways.