Multiple immune, inflammatory, and oncogenic signaling pathway components

The term 'Multiple immune, inflammatory, and oncogenic signaling pathway components' refers to a broad array of intracellular networks, such as the Janus kinase-signal transducer and activator of transcription (JAK-STAT) and nuclear factor kappa B (NF-κB) pathways, which are essential for mediating cellular responses to cytokines and growth factors (Rawlings et al., 2004, J Cell Sci; Oeckinghaus & Ghosh, 2009, Cold Spring Harb Perspect Biol). These pathways play a central role in the regulation of the immune system and the execution of inflammatory responses, but their dysregulation is frequently implicated in the development and progression of various cancers (Yu et al., 2014, Nat Rev Cancer). Therapeutic agents like JAK inhibitors (e.g., tofacitinib) and proteasome inhibitors (e.g., bortezomib) target these components to treat autoimmune diseases and malignancies by modulating gene expression and inducing apoptosis (Villarino et al., 2017, Nat Rev Immunol). However, because these signaling components are involved in numerous physiological processes, their pharmacological inhibition can lead to significant safety concerns, including systemic immunosuppression and an increased risk of opportunistic infections (O'Shea et al., 2013, Nat Rev Drug Discov). Consequently, these pathways represent a complex therapeutic landscape where selectivity is crucial for balancing efficacy and safety.

Other names

Immune signaling pathwaysInflammatory signaling pathwaysOncogenic signaling pathwaysJAK-STAT signaling componentsNF-kappaB signaling components

Modulation of intracellular signaling nodes, such as Janus kinases or the proteasome, to regulate the transcription of genes involved in immunity, inflammation, and cell survival (Villarino et al., 2017, Nat Rev Immunol).