Multiple Immune and Stromal Cell Pathways

"Multiple Immune and Stromal Cell Pathways" describes the coordinated, often bidirectional, interaction networks between immune cells (e.g., lymphocytes, macrophages, dendritic cells) and stromal cells (e.g., fibroblasts, endothelial cells, mesenchymal stem cells) in tissues. These pathways regulate inflammation, tissue repair, homeostasis, and disease progression through cell signaling, secretion of soluble factors, and extracellular matrix remodeling. In cancer and autoimmunity, immune-stromal crosstalk mediates tumor immune evasion, metastasis, fibrosis, and modulates responses to immunotherapies. Understanding these pathways is central to devising therapies that alter the tumor microenvironment, suppress unwanted inflammation, or improve tissue regeneration. Because this term does not designate a unique, actionable molecular target or receptor, it is unsuited for direct drug targeting, and refers instead to a research domain encompassing many potential actionable targets. If a specific molecule or target within these pathways is intended (e.g., "PD-L1", "Transforming growth factor beta receptor", "Fibroblast activation protein"), please clarify for a more targeted entry.