Target intelligence / Profile preview

Multiple immune cell surface antigens

Molecular classification
Receptor, Ligand, Transporter, Enzyme, Major histocompatibility complex (MHC), Immunoglobulin superfamily, Other glycoproteins
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Overview

Multiple immune cell surface antigens is a collective term for the diverse array of molecules expressed on immune cell membranes, including clusters of differentiation (CD) markers, major histocompatibility complex molecules, chemokine receptors, and other glycoproteins. These antigens allow immune cells to participate in critical biological functions such as antigen recognition, intercellular signaling, immune response regulation, and cell trafficking. Their differential expression is key to immune cell lineage identification (e.g., T cells, B cells, NK cells, macrophages) and to the selection of targeted therapies in cancer and chronic disease. Because the term refers to a heterogenous group rather than a single molecular entity, it is considered an incorrect or non-specific target designation for structured data applications.

Other names
CD markersclusters of differentiationsurface antigensimmune cell markerscell surface antigens
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Mechanism of action

Direct cellular cytotoxicity; Immune checkpoint blockade; Antibody-dependent cell-mediated cytotoxicity (ADCC); Complement activation; Immune modulation through receptor/ligand engagement

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Biological functions

Cell signalingImmune recognitionCell-cell interactionAntigen presentationImmune cell activationHoming and migrationPathogen recognitionRegulation of immune response
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Disease associations

Cancer (tumor immunophenotyping, immunotherapy target)InfectionAutoimmune diseasesInflammationTransplant rejection
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Safety considerations

Off-target immune effects (cytokine release syndrome, autoimmunity)ImmunosuppressionInfection risk (due to immune cell depletion)Infusion reactionsResistance and antigen escape variants
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Interacting drugs

Rituximab (targets CD20)

5 more in the full profile.

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Biomarkers

CD3, CD4, CD8 (T cell subset markers)CD19, CD20 (B cell markers)CD56, CD16 (NK cell markers)CD68, CD80, CD163, CD206 (macrophage polarization markers)MHC class I, class II (HLA typing)Many others based on disease context

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