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Target intelligence / Profile preview
Multiple Immune-Inflammatory Pathways
- Molecular classification
- Signaling pathway, Immune pathway, Inflammatory pathway
01
Overview
Multiple immune-inflammatory pathways refer to the complex, interconnected signaling networks and cellular processes that mediate both the initiation and resolution of inflammation in response to infection, tissue injury, or autoimmunity. These pathways involve a wide range of immune cells (innate and adaptive), cytokines, chemokines, transcription factors, and intracellular signaling cascades. Dysregulation across these pathways underlies many diseases.
02
Mechanism of action
Various, depending on the specific drug and target within the pathways; examples include cytokine blockade, transcription factor inhibition, and enhancement of pro-resolving mechanisms.
03
Biological functions
Immune responseInflammationHost defenseTissue repairSignal transductionCell recruitmentCytokine production
04
Disease associations
Autoimmune diseasesChronic inflammatory diseasesCytokine stormSepsisViral infectionsRheumatoid arthritisMultiple sclerosisInflammatory bowel diseaseAtherosclerosisFibrosis
05
Safety considerations
ImmunosuppressionIncreased risk of infectionOff-target effects due to pathway redundancyCompensatory mechanisms limiting efficacyCytokine release syndrome
06
Interacting drugs
Anti-TNF therapies
2 more in the full profile.
07
Biomarkers
Cytokine levels (e.g., IL-1β, IL-6, TNF-α, IL-10)Chemokine levelsInflammatory cell countsAcute phase proteinsGenetic risk loci
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