Multiple immune-related proteins

Multiple immune-related proteins is a collective term used in biomedical research to describe a broad group of proteins—including cytokines, chemokines, and cell surface receptors—that coordinate the body's immune response (Frontiers in Pharmacology, 2018). This term does not refer to a single, discrete molecular target but rather a functional category of proteins involved in signaling pathways that regulate innate and adaptive immunity (NCSU, 2019). In the context of diseases like multiple sclerosis and Alzheimer's disease, researchers profile multiple immune-related proteins to identify biomarkers and potential therapeutic nodes (Frontiers in Neurology, 2024; Consensus.app, 2025). Because it encompasses many different protein families, it is not a canonical therapeutic target; however, systemic treatments like intravenous immunoglobulin (IVIG) and corticosteroids are often described as modulating multiple immune-related proteins to achieve broad immunomodulatory effects (SelectScience, 2024). Modern drug discovery also explores the simultaneous modulation of these proteins using multi-target therapies or combination regimens to overcome resistance in cancer immunotherapy (Scientist.com, 2024). Overall, the term highlights the complexity of the immune network and the shift toward systems-level therapeutic interventions (IJIRSS, 2025).

Other names

Immune-related proteinsInflammatory proteinsImmune system proteinsImmune-related genes

Broad immunomodulation through the simultaneous targeting or regulation of various cytokines, cell surface receptors, and signaling molecules.