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Multiple Inflammatory Cytokines and Chemokines

Molecular classification
Cytokine, Chemokine, Interleukin, Interferon, Tumor Necrosis Factor
01

Overview

Multiple inflammatory cytokines and chemokines refer to a broad group of small, secreted proteins that play central roles in regulating inflammation and immune responses. These molecules act as intercellular messengers, coordinating the activation, migration, proliferation, differentiation, and survival of various immune cells during both normal immune surveillance and pathological inflammatory processes. Dysregulation of these mediators is implicated in numerous diseases, including autoimmune disorders, chronic inflammatory diseases, neuroinflammation, neurodegeneration, and infectious diseases.

02

Mechanism of action

Varies depending on the specific cytokine or chemokine. Examples include receptor antagonism, neutralizing antibodies, and inhibition of downstream signaling pathways.

03

Biological functions

Immune regulationInflammationChemotaxisCell activationCell proliferationCell differentiationCell survivalAngiogenesisTissue repair
04

Disease associations

Autoimmune disordersChronic inflammatory diseasesNeuroinflammationNeurodegenerative diseaseInfectious diseasesCancer
05

Safety considerations

Cytokine stormImmunosuppressionIncreased risk of infectionExacerbation of autoimmune diseases
06

Biomarkers

IL-1beta levelsIL-6 levelsTNF-alpha levelsIFN-gamma levelsCCL2/MCP-1 levelsCXCL10 levels

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