Multiple metabolic enzymes and methyltransferases

The term "Multiple metabolic enzymes and methyltransferases" refers to a broad collection of proteins rather than a single, well-defined therapeutic target. Metabolic enzymes catalyze various biochemical reactions essential for cellular homeostasis, including nutrient processing and energy production (NIH, 2023). Methyltransferases are a specific class of enzymes that transfer methyl groups to substrates like DNA, RNA, and proteins, playing a critical role in gene silencing and protein function (UniProt, 2024). Drugs targeting these groups, such as methotrexate or azacitidine, often exhibit broad polypharmacology by inhibiting several enzymes simultaneously to disrupt cancer cell growth (PubMed, 2022). However, because this term encompasses a wide array of unrelated proteins, it does not constitute a single, specific therapeutic target in drug discovery databases. Instead, it serves as a functional classification for agents with systemic metabolic or epigenetic effects.

The mechanism of action involves the competitive or non-competitive inhibition of various enzymes within metabolic pathways or the inhibition of methyl group transfer to biological macromolecules, thereby altering cellular metabolism and epigenetic landscapes (PubMed, 2022).