Multiple native cytokine, chemokine, and growth factor receptors in cardiac and vascular tissues

This target refers to a broad collection of signaling receptors located in the heart and vasculature that mediate the effects of pro-inflammatory and pro-fibrotic molecules. It encompasses several distinct protein families, including chemokine receptors (GPCRs), cytokine receptors, and growth factor receptors (RTKs) such as those for VEGF and FGF. These receptors are central to the regulation of vascular permeability, leukocyte extravasation, and cardiac remodeling in response to injury. The therapeutic strategy involving this target typically employs multi-target agents like Pentosan Polysulfate Sodium (PPS), which sequester ligands and modulate receptor activity to treat chronic inflammatory conditions. While effective in dampening complex inflammatory cascades, the lack of specificity to a single molecular entity classifies this as a multi-target profile rather than a discrete protein target (Source: NIH PubChem; Paradigm Biopharmaceuticals).

Other names

Cytokine receptorsChemokine receptorsGrowth factor receptorsHeparin-binding protein receptors

Pentosan polysulfate sodium (PPS) acts as a glycosaminoglycan mimetic, binding to the heparin-binding domains of various ligands and their receptors to inhibit downstream signaling pathways associated with inflammation and tissue degradation (Source: Paradigm Biopharmaceuticals; Ghosh et al., 2010).