Multiple predicted human and viral targets

The term Multiple predicted human and viral targets is a non-specific descriptive label rather than a distinct biological entity or therapeutic target. It is commonly used in computational biology and polypharmacology to refer to a collection of proteins—both from the human host and a pathogen—that are hypothesized to interact with a specific compound or set of compounds. For instance, in the context of COVID-19 research, this designation might encompass viral proteins like the Main Protease (Mpro) and RNA-dependent RNA polymerase (RdRp), alongside human proteins like Angiotensin-Converting Enzyme 2 (ACE2) or Transmembrane Protease Serine 2 (TMPRSS2) (PMID: 32216086). Because this entry aggregates various unrelated molecular species, it does not possess a unique canonical structure, specific molecular classification, or a singular biological function. In drug development, targeting multiple pathways simultaneously is a strategy for broad-spectrum antivirals, but for the purposes of precise target annotation, this entry is considered incorrect due to its lack of specificity (PMID: 32526211). Consequently, it cannot be assigned a standard mechanism of action or a specific set of biomarkers for patient selection.

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