Multiple predicted targets inferred from similar Bushen formulas

The term Multiple predicted targets inferred from similar Bushen formulas does not refer to a single biological molecule but rather to a collective set of proteins and genes identified through network pharmacology as common targets for Traditional Chinese Medicine (TCM) kidney-tonifying (Bushen) prescriptions. These formulas, such as Bushen Huoxue and Bushen Yisui, are traditionally used to treat conditions related to aging, reproductive health, and skeletal integrity. Research utilizing network analysis often identifies a core group of hub targets—including AKT Serine/Threonine Kinase 1 (AKT1), Tumor Necrosis Factor (TNF), Interleukin 6 (IL6), and Estrogen Receptor 1 (ESR1)—that are modulated by the various chemical constituents of these herbal mixtures (Zhang et al., 2020, Evidence-Based Complementary and Alternative Medicine). These targets are involved in critical signaling pathways such as the PI3K/Akt, MAPK, and TNF pathways, which regulate inflammation, bone metabolism, and cellular survival (Li et al., 2021, Frontiers in Pharmacology). Because this entry describes a methodology-derived group of distinct proteins rather than a specific receptor or enzyme, it is classified as an incorrect designation for a single therapeutic target.

Other names

Bushen formula targetsKidney-tonifying TCM targetsPredicted targets of Bushen prescriptionsCommon targets of kidney-tonifying formulas

Synergistic modulation of multiple signaling pathways, including PI3K/Akt, MAPK, and FoxO, to restore homeostatic balance and tonify kidney function according to Traditional Chinese Medicine principles (Zhang et al., 2020).