Multiple protein targets of polyphenols and tannins in burnt hawthorn and burnt malt

The term Multiple protein targets of polyphenols and tannins in burnt hawthorn and burnt malt refers to a broad set of biological molecules identified through network pharmacology that interact with the chemical constituents of charred Crataegus pinnatifida (burnt hawthorn) and Hordeum vulgare (burnt malt). In Traditional Chinese Medicine (TCM), the charring process, known as Paozhi, is used to enhance the digestive properties of these herbs by altering their polyphenol and tannin profiles (Source: Journal of Ethnopharmacology). These compounds target various digestive enzymes, including alpha-amylase, alpha-glucosidase, and pepsin, to facilitate the breakdown of carbohydrates and proteins (Source: PubMed, PMID: 32854321). Furthermore, research indicates that these polyphenols interact with systemic targets such as Prostaglandin-endoperoxide synthase 2 (PTGS2), AKT1, and Tumor Necrosis Factor (TNF), which helps mitigate gastrointestinal inflammation and regulate metabolic homeostasis (Source: Evidence-Based Complementary and Alternative Medicine). Because this entry describes a multi-component pharmacological profile involving dozens of distinct proteins rather than a single molecular entity, it is classified as a research topic or complex rather than a single canonical therapeutic target. It represents the synergistic mechanism of action characteristic of polyherbal TCM formulations used for treating dyspepsia and related metabolic disorders.

Other names

Shanzha Tan and Maiya Tan targetsTargets of charred hawthorn and malt polyphenolsJiao San Xian targets

Modulation of digestive enzyme activity (inhibition of alpha-amylase and alpha-glucosidase) and regulation of inflammatory signaling pathways (inhibition of COX-2 and TNF-alpha).