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Multiple Proteins Modified via Heme-Mediated Free Radical Generation (Heme-Modified Proteins)

Target: Heme-Modified Proteins
Molecular classification: Protein, Modified Protein

Overview

Multiple proteins serve as targets for heme-mediated generation of free radicals, primarily under conditions where cell-free heme interacts with peroxides. This results in broad-spectrum oxidative modifications affecting diverse amino acid residues across many different protein substrates, a mechanism central to several disease processes involving oxidative stress.

Other names: Heme-oxidized proteinsProteins modified by heme radicalsOxidatively modified proteins by hemeTargets of heme-induced oxidative stress

Mechanism of action

N/A

Biological functions

Various protein functions depending on the specific protein targetAffected by oxidative damageMay contribute to signaling pathways

Disease associations

Oxidative stress related diseasesInflammationNeurodegenerative diseasesCardiovascular diseasesHemolytic disorders

Safety considerations

Off-target effects of radical generationPotential for widespread cytotoxicityOverwhelming of antioxidant defenses

Interacting drugs

Antioxidants

Biomarkers

Oxidized protein levelsHeme levelsMarkers of oxidative stress

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