Multiple Receptor Tyrosine Kinases and related kinases (RTKs and Kinases)

This group represents closely related cell-surface and intracellular tyrosine kinases, most of which mediate growth factor signaling pathways implicated in cancer, angiogenesis, and developmental processes. They are validated targets for a variety of kinase inhibitors, with extensive roles in oncological and vascular diseases. The provided list should be considered a "kinase inhibition profile" rather than a single molecular target. Structured curation should capture each as its own canonical entry for any structured data system.

Other names

CD331EC 2.7.10.1CD333KDRCD309Kinase insert domain receptorFLK1CD140aCD140bCD135CD117KITStem cell factor receptorFLT4SRCavian sarcoma viral (v-src) oncogene homologCD350

ATP-competitive inhibition of kinase domains. Inhibition of downstream signaling leading to anti-proliferative, anti-angiogenic, and pro-apoptotic effects.