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Target intelligence / Profile preview
Multiple sclerosis-associated retrovirus envelope protein (None)
- Target
- None
- Molecular classification
- Envelope glycoprotein, Retroviral protein
01
Overview
The multiple sclerosis-associated retrovirus envelope protein (MSRV-Env) is an envelope glycoprotein encoded by the MS-associated retroviral element (MSRV), a member of the Human Endogenous Retrovirus-W (HERV-W) family. It acts as a potent agonist for Toll-like receptor 4 (TLR4), triggering pro-inflammatory responses and contributing to the pathogenesis of multiple sclerosis. GNbAC1, a monoclonal antibody, targets MSRV-Env to neutralize its pathogenic effects.
- Other names
- MSRV EnvpHERV-W EnvHERV-W EnvENV-SU (surface unit)Transmembrane unit
02
Mechanism of action
GNbAC1: Antagonizes MSRV-Env/TLR4 interaction, blocking downstream signaling and inflammation.
03
Biological functions
Receptor bindingImmune responseInflammationTLR4 signaling
04
Disease associations
Multiple SclerosisNeuroinflammationDemyelination
05
Safety considerations
Excessive TNF-alpha productionPotential for triggering autoimmune responses
06
Interacting drugs
GNbAC1
07
Biomarkers
Anti-pHERV-W Env IgG levelsMSRV-Env expression levels in serum/PBMCs/brain lesions
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