Multiple signaling pathways related to inflammation

"Multiple signaling pathways related to inflammation" is not a single molecule, receptor, or canonical therapeutic target. Instead, it refers collectively to several intracellular and intercellular signal transduction cascades that regulate inflammatory responses. Key examples include the nuclear factor kappa B (NF‑κB), mitogen‑activated protein kinase (MAPK), Janus kinase/signal transducer and activator of transcription (JAK/STAT), and phosphoinositide 3‑kinase/protein kinase B (PI3K/Akt) pathways[1][3][4]. These networks coordinate immune cell activation, cytokine production, cell survival/death decisions, and tissue responses during infection or injury. Dysregulation can lead to chronic inflammatory diseases and contribute to cancer progression[1][2][5]. While many drugs modulate components of these cascades—such as inhibitors targeting NF‑κB or JAK kinases—the term itself does not denote an actionable drug target but rather an area encompassing multiple potential targets within immunology and pharmacology[2][5].

Other names

Inflammatory signaling pathwaysInflammation-related signaling pathwaysSignaling cascades in inflammationPathways related to inflammation