Multiple soluble plasma proteins

Multiple soluble plasma proteins is a collective term referring to the heterogeneous mixture of proteins found in human plasma, including albumin, globulins, and fibrinogen. These proteins perform vital physiological roles such as maintaining colloid osmotic pressure, transporting lipids and hormones, and facilitating the immune response and blood coagulation [StatPearls, NBK542197]. In a pharmacological context, this term is typically used to describe the target of plasma-derived products or drugs that exhibit broad, non-specific binding across various blood proteins [DrugBank, DB00062]. Because it encompasses hundreds of distinct molecular entities with diverse functions, it is considered an imprecise designation for a specific therapeutic target in modern drug discovery, which favors well-defined molecular structures [NCBI, NBK22592]. Clinically, therapies involving these proteins are often used for volume expansion or as replacement therapy in conditions like hypovolemia, cirrhosis, or primary immunodeficiency [PubMed, 28633674].

Other names

Plasma proteinsSerum proteinsBlood proteinsCirculating proteins

The mechanism of action involves the replacement of deficient proteins to restore physiological function, the expansion of plasma volume to maintain hemodynamics, or the non-specific binding and neutralization of circulating pathogens and toxins [DrugBank, DB00062; StatPearls, NBK542197].