Multiple surface antigen on Neisseria meningitidis outer membrane vesicle

Multiple surface antigens on Neisseria meningitidis outer membrane vesicle" refers to the heterogeneous group of exposed proteins, lipoproteins, and lipopolysaccharides present on the surface of outer membrane vesicles (OMVs) naturally shed by Neisseria meningitidis. OMVs are spherical lipid bilayer particles (20–300 nm) structurally resembling the outer membrane of the bacterium, including major surface proteins such as porins (PorA, PorB), adhesion molecules (e.g., Opa, Opc), iron transporters (e.g., FetA), and immunologically active lipopolysaccharides (LPS), among others[2][3][5][6]. These vesicles play roles in bacterial pathogenesis (adhesion, immune evasion, modulation)[1][3], but are best known as the basis for meningococcal group B vaccines where their mixture of surface antigens elicits strain-specific protective immunity[5][6]. As a vaccine component, OMV antigen selection and purification is critical to ensure efficacy while minimizing reactogenicity (toxicity from LPS)[2]. The "target" is not any single purified molecule, but rather a complex mixture; for structured annotation, individual components (such as PorA, PorB, Opa) may need to be treated as distinct canonical antigens.

Other names

Neisseria meningitidis OMV antigensOuter membrane vesicle (OMV) surface antigens from Neisseria meningitidisMeningococcal OMV surface proteins

Induction of protective immunity as vaccine antigens Modulation or inhibition of immune cells (e.g., Opa protein binding to CEACAM1 inhibits T cell activation)[1]