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Multiple Targets
- Molecular classification
- Not Applicable
01
Overview
"Multiple targets" refers to a strategy where a molecule interacts with more than one biological target (proteins, genes, RNA) to address complex diseases by modulating several pathways. This contrasts with single-target drugs and involves polypharmacology, either intentional (multi-target drugs) or unintentional (off-target effects). Advantages include increased efficacy, reduced resistance, and synergistic effects, while challenges include off-target risks and complexity in design and validation. Modern methods involve computational modeling and screening against target panels.
- Other names
- PolypharmacologyMulti-Target Drug DiscoveryTargeting Multiple Pathways
02
Mechanism of action
Modulation of multiple biological targets and pathways simultaneously.
03
Biological functions
Drug ActionModulation of Biological Pathways
04
Disease associations
CancerNeurodegenerative DisordersInfectious DiseasesMultifactorial Diseases
05
Safety considerations
Off-target effectsIncreased risk of side effectsToxicity
06
Interacting drugs
Multi-Target Drugs
3 more in the full profile.
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