Multiple Targets Including Anti-Inflammatory Pathways

A class of therapeutic strategies or compounds that exert anti-inflammatory effects by modulating several molecular and cellular pathways, rather than acting on a single, well-defined receptor or protein. These strategies often target multiple interconnected signaling routes such as MAPKs, NF-kB/JAK-STAT axis, arachidonic acid metabolism enzymes like COXs/LOXs, nuclear hormone receptors like PPARs, and pattern recognition molecules such as TLRs. The precise molecular targets are often not fully characterized, especially in the case of natural products or multi-component drugs, making mechanistic elucidation challenging.

Other names

Anti-inflammatory pathwaysInflammatory signaling cascadesMultiple inflammatory targetsNetwork pharmacology (anti-inflammatory)

Varies depending on the specific targets modulated; includes inhibition of kinase activity, suppression of transcription factor activation, enzyme inhibition, modulation of receptor signaling, and alteration of cytokine production.