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Multiple Targets of Cytotoxic Chemotherapy
- Molecular classification
- DNA, Enzymes, Topoisomerases, Structural Proteins
01
Overview
Cytotoxic chemotherapeutic agents target various molecules and pathways essential for rapid cell division. These include DNA (targeted by alkylating agents and cytotoxic antibiotics), enzymes involved in nucleotide synthesis (targeted by antimetabolites), topoisomerases I and II (targeted by topoisomerase inhibitors), and tubulin/microtubules (targeted by microtubule-targeting agents). This broad targeting underlies both their efficacy against various cancer types and their characteristic toxicities in normal, rapidly dividing tissues.
- Other names
- Targets of Alkylating AgentsTargets of AntimetabolitesTargets of Cytotoxic AntibioticsTargets of Topoisomerase InhibitorsTargets of Microtubule-targeting AgentsDNAEnzymes involved in nucleotide synthesisTopoisomerases I & IITubulin/microtubules
02
Mechanism of action
Disruption of genomic integrity, inhibition of nucleotide metabolism, interference with mitotic machinery
03
Biological functions
DNA replicationDNA transcriptionNucleotide synthesisDNA repairCell divisionMitosisMicrotubule dynamics
04
Disease associations
Cancer
05
Safety considerations
MyelosuppressionMucositisGastrointestinal toxicityAlopecia
06
Interacting drugs
Cyclophosphamide
9 more in the full profile.
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