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Target intelligence / Profile preview
Multiple Tumor-Associated and Cancer-Testis Antigens (N/A)
- Target
- N/A
- Molecular classification
- Tumor-Associated Antigen, Cancer-Testis Antigen, Apoptosis Inhibitor (Survivin), Transcription Factor (MAGE-A4, SSX2, PRAME), Cellular Antigen
01
Overview
Multiple tumor-associated and cancer-testis antigens (TAAs/CTAs) including Survivin, NY-ESO-1, MAGE-A4, SSX2, and PRAME are a group of proteins overexpressed in various cancers with limited expression in normal tissues. They are attractive targets for cancer immunotherapy due to their immunogenicity and role in tumor cell survival and proliferation. Targeting these antigens aims to elicit anti-tumor immune responses, but potential safety concerns and variable efficacy remain challenges.
- Other names
- SurvivinNY-ESO-1MAGE-A4SSX2PRAMEBIRC5CTAG1BMAGEA4Cancer-Testis AntigensTumor-Associated Antigens
02
Mechanism of action
Induction of anti-tumor immune response via T-cell activation and antibody production; inhibition of apoptosis (Survivin); modulation of gene expression (MAGE-A4, SSX2, PRAME)
03
Biological functions
Immune responseCell survivalCell proliferationApoptosis inhibition (Survivin)Mitosis regulation (Survivin)Tumorigenesis
04
Disease associations
CancerTumor growthMetastasisImmune evasion
05
Safety considerations
Potential for off-target toxicityAutoimmunityCytokine release syndromeLimited efficacy in some patients
06
Interacting drugs
Peptide vaccines
3 more in the full profile.
07
Biomarkers
NY-ESO-1 expressionMAGE-A4 expressionSurvivin expressionSSX2 expressionPRAME expressionAntibody titers against NY-ESO-1
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