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Target intelligence / Profile preview
Multiple Tumor-Associated Antigens (TAAs)
- Target
- TAAs
- Molecular classification
- Protein, Glycoprotein, Oncofetal Antigen, Cancer-Testis Antigen, Differentiation Antigen, Altered Cell Surface Glycolipid, Altered Cell Surface Glycoprotein
01
Overview
Multiple tumor-associated antigens (TAAs) are molecules present at elevated levels on tumor cells, but also found at lower levels on normal cells. They include proteins, glycoproteins, oncofetal antigens, cancer-testis antigens, and altered cell surface molecules. TAAs play roles in cell growth, signaling, apoptosis, immune evasion, and stemness. They are used for diagnostic and therapeutic purposes, including targeted therapies and immunotherapies. Challenges include off-target toxicity due to expression in normal tissues.
- Other names
- Tumor Associated AntigensTAA
02
Mechanism of action
Antibody-dependent cell-mediated cytotoxicity (ADCC), Complement-dependent cytotoxicity (CDC), Inhibition of receptor signaling
03
Biological functions
Cell growth regulationSignal transductionApoptosis inhibitionImmune evasionMaintenance of stemnessCell differentiation
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityImmune-related adverse events
06
Interacting drugs
Rituximab
1 more in the full profile.
07
Biomarkers
p53 mutations (autoantibodies)HER2 expressionCD20 expressionPSA levelsCEA levels
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