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Multiple Tumor Cell Signaling Pathways

Molecular classification: Intracellular signaling networks

Overview

Elemene, particularly β-elemene, targets multiple tumor cell signaling pathways simultaneously, including MAPK/ERK, PI3K/Akt/mTOR, NF-κB, JAK/STAT, and Wnt/β-catenin. This multi-targeted approach disrupts the complex network that allows cancer cells to survive, leading to induction of apoptosis, promotion of autophagy, cell cycle arrest, inhibition of multidrug resistance, and suppression of EMT, ultimately overcoming chemoresistance and exerting broad-spectrum antitumor effects.

Mechanism of action

Modulates gene/protein expression across pathways: induces apoptosis/autophagy/cell cycle arrest/inhibits MDR transporters

Biological functions

Regulation of proliferationSurvival/apoptosis balanceMigration/invasion/metastasisCell cycleSignal transduction

Disease associations

Cancer

Interacting drugs

Elemene

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