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Target intelligence / Profile preview
Multiple tumor-related signaling pathways
- Molecular classification
- Signaling pathway, Protein-protein interaction network
01
Overview
Multiple tumor-related signaling pathways refer to a network of interconnected molecular cascades that regulate key processes in cancer, including cell proliferation, survival, metastasis, invasion, and drug resistance. These pathways are frequently dysregulated in malignant tumors and represent critical targets for therapeutic intervention. Key pathways include Wnt/β-catenin, PI3K/AKT/mTOR, MAPK, Notch, and NF-kB. Targeting single nodes often leads to limited efficacy due to compensatory mechanisms within the network, necessitating multi-targeted agents or combination therapies.
- Other names
- Cancer signaling pathwaysOncogenic signaling pathwaysTumorigenic pathways
02
Mechanism of action
Inhibition of specific kinases or proteins within the signaling pathways to disrupt cancer cell growth and survival.
03
Biological functions
Cell proliferationCell survivalApoptosisAngiogenesisMetastasisDrug resistanceImmune evasionCell differentiation
04
Disease associations
Cancer
05
Safety considerations
Drug resistanceOff-target effectsCompensatory pathway activationCrosstalk with other signaling pathways
06
Interacting drugs
PI3K inhibitors
5 more in the full profile.
07
Biomarkers
PIK3CA mutationsPTEN lossRAS mutationsBRAF mutationsAPC mutationsNOTCH mutations
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