Multiple Tyrosine Kinases (TKs)

Tyrosine kinases are a large family of enzymes that catalyze the transfer of phosphate groups from ATP to tyrosine residues on protein substrates, a process known as phosphorylation. This modification is crucial for regulating cellular signaling pathways involved in growth, differentiation, metabolism, and survival. The family includes receptor tyrosine kinases (RTKs), transmembrane proteins activated by ligand binding, and non-receptor tyrosine kinases, located in the cytoplasm or nucleus, that participate in signal transduction cascades. Aberrant tyrosine kinase activity is implicated in numerous diseases, particularly cancer.

Other names

Tyrosine Kinase FamilyReceptor Tyrosine Kinases (RTKs)Non-Receptor Tyrosine KinasesCytoplasmic Tyrosine Kinases

Inhibition of tyrosine kinase activity, blocking downstream signaling pathways.