Multiple undefined plasma protein targets

Multiple undefined plasma protein targets is a collective term used to describe a broad array of proteins found in the blood plasma, including albumin, globulins, and lipoproteins, that interact with drugs in a non-specific or poorly defined manner (ChEMBL, 2024, https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2363065/). These proteins primarily function in the transport of endogenous molecules like hormones and fatty acids, the maintenance of oncotic pressure, and the regulation of the immune and coagulation systems (StatPearls, 2023, https://www.ncbi.nlm.nih.gov/books/NBK459122/). While they are essential for physiological homeostasis, they are rarely the intended therapeutic targets for disease modification; instead, they often act as a pharmacokinetic sink that influences a drug's volume of distribution and half-life (PubMed, 2008, https://pubmed.ncbi.nlm.nih.gov/18466346/). This classification is frequently applied to diagnostic agents, such as Indocyanine green or Evans blue, which rely on binding to albumin to remain within the vasculature for imaging purposes (DrugBank, 2024, https://go.drugbank.com/drugs/DB00659). Because this term represents an aggregate of various molecular entities rather than a single specific receptor or enzyme, it is considered an undefined or non-specific target in pharmacological databases. Understanding the interaction with these proteins is critical for managing safety, as the displacement of highly protein-bound drugs can lead to significant toxicity (NIH, 2023, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144753/).

Other names

Plasma proteinsSerum proteinsBlood proteinsNon-specific plasma protein binding sites

Non-specific binding to various plasma proteins to facilitate intravascular retention, diagnostic imaging, or to influence the pharmacokinetic distribution of a compound.