Multiple viral and host proteins

"Multiple viral and host proteins" refers to the ensemble of proteins encoded by viruses and their corresponding interacting partners in the host organism's proteome. These interactions govern essential processes such as viral entry, replication, immune modulation, and pathogenesis. The term is not a canonical molecular target but rather comprises thousands of unique protein-protein interactions across diverse viral and host genomes. Therapeutically, targeting virus-host protein interactions (rather than viral proteins alone) is a strategy to combat infection, increase the genetic barrier to resistance, and potentially enable broad-spectrum antiviral development. However, such approaches must carefully balance antiviral efficacy with preservation of normal host cell biology due to possible off-target effects[1][5][7]. This entry is too broad and non-specific to be considered a valid individual drug target for most structured therapeutic databases. Instead, each involved virus or host protein (e.g., CCR5, ACE2) would constitute a separate, manageable entry[1][5][7].

Other names

Virus-host interaction proteinsViral-host protein-protein interactions (PPIs)Host dependency factors (when referring to host proteins essential for viral infection)

Inhibition of critical virus-host protein-protein interactions Modulation of host pathways essential for viral replication[1][5][7]