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Multipotent stem cell (MSC (for mesenchymal stem cell, a common multipotent stem cell); HSC (for hematopoietic stem cell, another multipotent example))
- Target
- MSC (for mesenchymal stem cell, a common multipotent stem cell); HSC (for hematopoietic stem cell, another multipotent example)
- Molecular classification
- Other (not a receptor, enzyme, transporter, channel, etc.; refers to a cell state/type)
01
Overview
Multipotent stem cells are undifferentiated cells capable of self-renewal and differentiation into a limited variety of specialized cell types within a specific tissue or lineage. They are essential for tissue homeostasis, repair, and regeneration, and are more restricted in developmental potential than pluripotent or totipotent stem cells. Examples include hematopoietic stem cells (producing blood cells), mesenchymal stem cells (producing bone, cartilage, fat), and neural stem cells (producing neuronal lineages). Multipotency is not a single molecule, receptor, or gene—it is a stem cell state, frequently characterized by a profile of surface markers that vary depending on the tissue of origin[1][2][3][4][5][6][7].
- Other names
- Multipotent stem celltissue-specific stem celladult stem cell
02
Biological functions
Cell proliferationTissue regenerationCell differentiationSelf-renewal
03
Disease associations
Cancer (multipotent stem cells may be implicated in cancer stem cell biology)Other (tissue repair after injury)
04
Safety considerations
Potential for unintended differentiation or tumorigenesis in regenerative therapiesImmune rejection risks with non-autologous stem cells
05
Biomarkers
CD34CD38CD90CD45CD133 (for hematopoietic stem cells)CD73CD105CD44CD146CD271STRO-1 (for mesenchymal stem cells)NestinPax6CD133Notch1 (for neural stem cells)CD49fCD24Lgr5Olfm4Bmi1 (for epithelial/intestinal stem cells)
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