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Target intelligence / Profile preview
Mumps Virus Fusion Protein (MuV-F)
- Target
- MuV-F
- Molecular classification
- Viral Fusion Protein, Class I viral fusion glycoprotein, Glycoprotein
01
Overview
The mumps virus fusion protein (MuV-F) is a class I viral fusion glycoprotein essential for the entry of the mumps virus into host cells. It mediates the fusion between the viral envelope and cellular membranes, enabling viral RNA to enter and infect host cells. The F protein is synthesized as an inactive precursor, F0, which is cleaved by host cell proteases into two subunits. This cleavage activates the protein for membrane fusion activity. The mature F protein facilitates both virus-cell and cell-cell membrane fusion, playing a critical role in viral entry and spread within tissues.
- Other names
- Fusion glycoprotein F0F proteinMuV-F protein
02
Mechanism of action
Inhibition of membrane fusion
03
Biological functions
Membrane fusionViral entryCell-cell fusionViral spread
04
Disease associations
InfectionMumps
05
Safety considerations
Variations at the cleavage site can affect fusogenicity and virulenceAntibody-dependent enhancement (ADE) of infection
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