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MurG glycosyltransferase
- Molecular classification
- Enzyme, Glycosyltransferase
01
Overview
MurG glycosyltransferase is an essential bacterial enzyme that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to lipid I (undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide), forming lipid II, a crucial precursor for peptidoglycan synthesis. Its essential role in bacterial cell wall biosynthesis makes it an attractive target for novel antibiotics.
02
Mechanism of action
Inhibition of peptidoglycan biosynthesis
03
Biological functions
Peptidoglycan biosynthesisCell wall synthesis
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects due to sequence homology with human glycosyltransferasesDevelopment of resistance in bacteria
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