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Target intelligence / Profile preview
Muscarinic Acetylcholine Receptor M1 (M1 mAChR)
- Target
- M1 mAChR
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The muscarinic acetylcholine receptor M1 (M1 mAChR or CHRM1) is a G protein-coupled receptor that mediates cellular responses to acetylcholine. It is highly expressed in the central nervous system and plays a critical role in cognitive processes, glandular secretion, and synaptic modulation. It is a target for drug development for neurological disorders. Antagonism of M1 can cause delirium.
- Other names
- CHRM1Muscarinic receptor M1
02
Mechanism of action
Agonists bind to the M1 receptor, activating Gq/11 proteins, leading to increased phospholipase C activity, IP3 production, and intracellular calcium levels. Antagonists block acetylcholine binding, inhibiting downstream signaling.
03
Biological functions
Signal transductionCognitive processingGlandular secretionSynaptic modulationLearning and memoryAttentionPerception
04
Disease associations
Neurodegenerative diseaseAlzheimer's diseaseDeliriumCognitive impairment
05
Safety considerations
Antagonism can induce delirium and hallucinationsPotential for cognitive side effects
06
Interacting drugs
Acetylcholine
3 more in the full profile.
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