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Target intelligence / Profile preview
Muscarinic Acetylcholine Receptor M3 Subtype (M3)
- Target
- M3
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The muscarinic acetylcholine receptor M3 subtype (M3, CHRM3) is a G protein-coupled receptor that mediates many of the physiological effects of acetylcholine. It is highly expressed in smooth muscle tissues, exocrine glands, endocrine glands, lungs, pancreas, and certain regions of the brain. Activation leads to smooth muscle contraction, glandular secretion, and vascular effects. It is targeted by therapeutic drugs for airway obstructive diseases, urge urinary incontinence, and irritable bowel syndrome.
- Other names
- CHRM3
02
Mechanism of action
Gq protein activation leading to Phospholipase C activation, IP3 and DAG production, and increased intracellular calcium concentration
03
Biological functions
Smooth muscle contractionGlandular secretionVascular effectsEmesis regulationInsulin homeostasis
04
Disease associations
Airway obstructive diseases (e.g., COPD)Urge urinary incontinence/overactive bladder syndromeIrritable bowel syndromeMyopia
05
Safety considerations
Side effects due to peripheral actions mediated via M3 receptors
06
Interacting drugs
M3-selective antagonists
1 more in the full profile.
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