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Target intelligence / Profile preview
Muscarinic Acetylcholine Receptor M5 (M5 mAChR)
- Target
- M5 mAChR
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The muscarinic acetylcholine receptor M5 (M5 mAChR) is a G protein-coupled receptor that mediates the effects of acetylcholine in the central and peripheral nervous systems. Primarily expressed in the brain, particularly on dopamine neurons, it modulates dopamine release and plays a role in behavioral flexibility and reward pathways. It is a potential therapeutic target for drug addiction and may be involved in Parkinson's disease pathophysiology.
- Other names
- CHRM5
02
Mechanism of action
Agonist binding leads to Gq/11 activation, PLCβ activation, IP₃/DAG production, and increased intracellular calcium. Inverse agonists like tiotropium reduce basal receptor activity.
03
Biological functions
Signal transductionDopamine modulationNeuromodulationPhosphoinositide hydrolysisCalcium signaling
04
Disease associations
Drug addictionParkinson's disease
05
Safety considerations
Potential for off-target effects due to muscarinic receptor family similarity; selectivity is key for therapeutic development.Modulation of dopamine pathways may lead to unintended behavioral changes.
06
Interacting drugs
Acetylcholine
1 more in the full profile.
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