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Target intelligence / Profile preview
Muscle Specific Kinase (MuSK)
- Target
- MuSK
- Molecular classification
- Receptor tyrosine kinase
01
Overview
Muscle specific kinase (MuSK) is a receptor tyrosine kinase that plays an essential role in the formation, maintenance, and function of the neuromuscular junction (NMJ), which is the synapse between motor neurons and skeletal muscle fibers. It interacts with Agrin and LRP4 to initiate signaling cascades essential for NMJ development and maintenance. Autoantibodies against MuSK are found in some patients with myasthenia gravis, and mutations affecting the MUSK gene can cause congenital myasthenic syndromes.
02
Mechanism of action
Modulation of MuSK activity to enhance neuromuscular transmission.
03
Biological functions
Formation of neuromuscular junctionMaintenance of neuromuscular junctionAcetylcholine receptor clusteringSynaptic protein transcriptionPresynaptic differentiation
04
Disease associations
Myasthenia gravisCongenital myasthenic syndromes
05
Safety considerations
Potential for unintended effects on neuromuscular function
06
Biomarkers
MuSK autoantibodies (in myasthenia gravis)
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