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Target intelligence / Profile preview
Muscle-Specific Kinase Receptor (MuSK)
- Target
- MuSK
- Molecular classification
- Receptor Tyrosine Kinase, Receptor
01
Overview
Muscle-specific kinase (MuSK) is a receptor tyrosine kinase essential for the formation, maintenance, and function of the neuromuscular junction (NMJ). Activated by agrin and LRP4, MuSK triggers AChR clustering and synaptic protein transcription. Autoantibodies against MuSK cause MuSK-MG, characterized by impaired NMJ function.
- Other names
- Muscle-specific tyrosine kinase receptorMUSK protein
02
Mechanism of action
Blocking MuSK signaling with autoantibodies leads to impaired neuromuscular junction function and downstream consequences in the disease myasthenia gravis.
03
Biological functions
Formation of neuromuscular junctionsMaintenance of neuromuscular junctionsClustering of acetylcholine receptors (AChRs)Synaptic protein transcriptionRetrograde signaling
04
Disease associations
Myasthenia gravis (MuSK-MG)Congenital myasthenic syndromes
05
Safety considerations
Immunosuppression side effects in MuSK-MG treatment
06
Biomarkers
MuSK autoantibodies
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