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Target intelligence / Profile preview
Musculin (MSC)
- Target
- MSC
- Molecular classification
- Transcription factor, Basic helix-loop-helix (bHLH) protein, Transcriptional corepressor
01
Overview
Musculin (MSC) is a basic helix-loop-helix transcriptional repressor capable of binding E-box elements as a homodimer or as a heterodimer with E2A proteins such as TCF3/E47[1][6]. It primarily functions to inhibit the transcriptional activity of E47, thereby acting as a negative regulator of antigen-dependent B-cell differentiation and is a downstream target of the B-cell receptor signal transduction pathway[1]. It also modulates human T-helper 17 cell responses to interleukin 2, influencing STAT5B activity in immune regulation[5]. Musculin is associated with diseases such as rhabdomyosarcoma and severe congenital neutropenia, X-linked[1]. Its paralog is TCF21, and it may play context-specific roles in cellular development and immune cell differentiation[2][4][5].
- Other names
- ABF1ABF-1BHLHA22bHLHa22Activated B-cell factor 1Class A basic helix-loop-helix protein 22MYORactivated B-cell factor-1homolog of mouse musculin
02
Biological functions
DNA-binding transcription factor activityTranscription corepressor activityRegulation of antigen-dependent B-cell differentiationInhibition of transactivationRegulation of T-helper 17 cell response to interleukin 2
03
Disease associations
Cancer (including rhabdomyosarcoma)Immune regulation (Neutropenia, Severe Congenital, X-Linked)Other
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