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Musculoskeletal system function optimization" refers to a set of computational, engineering, and clinical methods aimed at improving the biomechanical efficiency, control, or rehabilitation of the combined muscle and skeletal structures within the body. It does not indicate a single biomolecular entity but involves the integration of muscle force modeling, joint trajectory planning, and the application of optimization techniques (such as static or dynamic optimization) to predict or modulate system-wide function for purposes such as movement rehabilitation, injury prevention, or surgical planning[1][2][3][4][5][6][7]. These approaches model the mechanical and neural control of muscles and bones and are used in orthopedics, physical therapy, and robotics but are not synonymous with any single druggable target or defined therapeutic receptor.
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