Muskelin 1 (MKLN1)

Muskelin 1 (MKLN1) is an intracellular scaffold protein encoded by the MKLN1 gene on chromosome 7q32.3[1][2][5]. It is characterized by multiple conserved domains: N-terminal discoidin domain; LisH and CTLH alpha-helical domains; a kelch repeat β-propeller domain; and a C-terminal CRA domain[1]. Muskelin 1 is a component of the CTLH E3 ubiquitin-protein ligase complex, which submits specific substrate proteins for ubiquitination and degradation via the 26S proteasome, thereby regulating widespread cellular processes such as cell spreading, cytoskeletal dynamics, cell migration, and transcription factor turnover[1][2][7]. In neurons, muskelin 1 is required for internalization and degradation of the GABA receptor GABRA1 and can regulate its own levels by self-ubiquitination[2][7]. Although muskelin 1 is broadly expressed from embryogenesis to adulthood and regulates multiple protein networks in various tissues, genetic studies implicate it predominantly in neurological function and disorders[1][2]. There is no evidence of muskelin 1 being directly targeted by drugs nor used as a therapeutic biomarker in clinical practice.

Other names

Muskelin 1MuskelinMKLN1TWA2Intracellular mediator containing kelch motifs

Not applicable. There is no drug mechanism of action reported for muskelin 1 since no drugs target it[2][5][7].