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Target intelligence / Profile preview
Mutant Receptor Tyrosine Kinase (Mutant RTK)
- Target
- Mutant RTK
- Molecular classification
- Receptor, Enzyme, Protein Kinase, Receptor Tyrosine Kinase
01
Overview
Mutant receptor tyrosine kinases (RTKs) are altered forms of cell surface receptors that exhibit constitutive or dysregulated tyrosine kinase activity. These mutations, which can be germline or somatic, often lead to uncontrolled cell growth, survival, and proliferation, contributing to developmental disorders and various cancers. They are major targets for anticancer drugs.
- Other names
- Mutated Receptor Tyrosine KinaseActivating RTK mutantsOncogenic RTKs
02
Mechanism of action
Inhibition of tyrosine kinase activity, blockade of ligand binding
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalApoptosis regulationCell migrationCell-to-cell communicationMorphogenesisAutophagy
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Off-target effectsDrug resistanceDevelopment of secondary malignanciesSpecific toxicities related to individual RTK inhibitors
06
Interacting drugs
Small molecule inhibitors
1 more in the full profile.
07
Biomarkers
Specific RTK mutation types (e.g., EGFR mutations in lung cancer, MET mutations in renal carcinoma)Phosphorylation status of RTK and downstream targets
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