MYADM antisense RNA 2 (MYADM-AS2)

MYADM antisense RNA 2 (MYADM-AS2), also known as VEAL2, is a long non-coding RNA arising antisense to the 3' UTR of the myeloid-associated differentiation marker (MYADM) gene[1][9][10]. As an endothelial-enriched lncRNA, it acts as a critical endogenous regulator of endothelial barrier function and angiogenesis. MYADM-AS2 binds to the C1 domain of Protein kinase C beta (specifically PRKCB2), competing with diacylglycerol and thereby restraining PRKCB2 activation. Its knockdown or absence increases vascular permeability and disrupts endothelial junctions, while overexpression attenuates hyperpermeability, particularly in pathological states such as diabetic retinopathy. These properties suggest its emerging potential as both a biomarker for microvascular complications and a therapeutic target for vascular diseases with dysregulated PRKCB2 activity[1][4][5][7][10].

Other names

VEAL2vascular endothelial-associated lncRNA 2

Competitive inhibition of diacylglycerol binding to PRKCB2 via direct interaction. Regulation of endothelial junctional protein turnover, thus controlling vascular permeability.