MYB antisense RNA 1 (MYB-AS1)

MYB antisense RNA 1 (MYB-AS1) is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the MYB gene locus on chromosome 6 in humans. Unlike protein-coding genes, MYB-AS1 does not encode a protein; instead, it likely plays a regulatory role at the RNA level. Through antisense interactions, it is believed to influence the expression of the MYB proto-oncogene, which is involved in cell proliferation, differentiation, and tumorigenesis. MYB-AS1 is implicated in diseases such as cancer due to its impact on MYB regulation, but it is not itself a therapeutic target nor an enzyme, receptor, or structural protein. No drugs are known to interact with MYB-AS1 directly, though its modulation could theoretically affect diseases where MYB is a key driver. \n\nNote: Be careful not to confuse MYB-AS1 (the lncRNA) with the protein-coding MYB transcription factor, which is a well-studied proto-oncogene and transcriptional regulator.

Other names

RP1-32B1.3NCRNA00209Non-protein coding RNA 209MYB-ASMYBASMYB antisense RNA 1 (full variant name)

Not a direct therapeutic target; acts by regulating the expression of the MYB gene at the RNA level, primarily by antisense-mediated mechanisms