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Target intelligence / Profile preview
MYB proto-oncogene protein (c-Myb)
- Target
- c-Myb
- Molecular classification
- Transcription factor
01
Overview
The MYB mRNA encodes for the c-Myb protein, a transcription factor that plays a crucial role in hematopoiesis and cell cycle regulation. It contains three helix-turn-helix DNA-binding domains and regulates the expression of genes involved in cell proliferation and differentiation. Dysregulation of MYB, through mutations or altered expression, is strongly linked to various cancers.
- Other names
- MYBavian myeloblastosis viral oncogene homolog
02
Biological functions
Transcription regulationHematopoiesisCell proliferationCell differentiationCell cycle progression
03
Disease associations
CancerLeukemiaLymphomaAdenoid cystic carcinomaAngiocentric gliomaColon cancerBreast cancer
04
Safety considerations
Aberrant expression can lead to oncogenesisMutations can convert it into a transforming protein
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