MYC-induced long non-coding RNA (MINCR)

MYC-induced long non-coding RNA (MINCR) is a long non-coding RNA (lncRNA) that is directly upregulated by the transcription factor MYC in various human cancers, especially in MYC-positive B-cell lymphomas[1][3][5]. MINCR is primarily nuclear, with multiple isoforms, and lacks significant protein-coding potential[1]. Functionally, MINCR modulates the transcriptional program of MYC, particularly by influencing the expression and promoter binding of MYC-regulated cell cycle genes, such as Aurora kinases and CDK2[1]. Knockdown of MINCR leads to cell cycle arrest and increased apoptosis, indicating its role in supporting malignant cell proliferation[1]. MINCR has been linked to the pathogenesis and prognosis of several cancers, positioning it as both a biomarker and a potential novel therapeutic target; however, direct drug targeting strategies are currently lacking[3][5].

Other names

LINC01604TCONS_00015189long intergenic non-protein coding RNA 1604NR_120682.1NR_120683.1ENSG00000253716LOC100507316

Modulation of MYC transcriptional activity, Regulation of MYC target gene expression, Potential recruitment of MYC co-activators to gene promoters, Modulation of MYC binding to target promoters