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MYC Proto-Oncogene, BHLH Transcription Factor (MYC)
- Target
- MYC
- Molecular classification
- Transcription factor, Proto-oncogene, bHLH-LZ protein
01
Overview
MYC is a proto-oncogene encoding a transcription factor that regulates the expression of genes involved in cell growth, proliferation, metabolism, apoptosis, and differentiation. It forms a heterodimer with MAX to bind DNA and activate/repress gene expression. MYC is frequently dysregulated in cancer, driving uncontrolled proliferation and tumor development.
- Other names
- c-MYCMYCbHLHe39
02
Mechanism of action
MYC inhibitors aim to disrupt MYC-MAX dimerization, inhibit MYC transcription, or target downstream MYC-dependent processes.
03
Biological functions
Cell cycle progressionCell growthMetabolism regulationApoptosis regulationTranscriptional regulationRibosome biogenesisNutrient transport regulationDifferentiation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to broad transcriptional regulationToxicity associated with inhibiting essential cellular processesDevelopment of resistance
06
Biomarkers
MYC protein levelsMYC gene amplificationExpression of MYC target genes
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