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Target intelligence / Profile preview
MYCL antisense RNA 1 (MYCL-AS1)
- Target
- MYCL-AS1
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
MYCL antisense RNA 1 (MYCL-AS1), also known as MYCLos-1, is a long non-coding RNA (lncRNA) transcribed antisense to the MYCL gene. It is involved in the regulation of MYC target genes such as CDKN1A (encoding p21) and CDKN2B (encoding p15), primarily by interacting with RNA-binding proteins like HuR and modulating promoter activity in target genes. MYCL-AS1 is part of a complex regulatory network downstream of the MYC proto-oncogene, influencing cell cycle progression, cell proliferation, and tumor-suppressive pathways. Its altered expression and function are associated with cancer cell biology but, as of the current evidence, it is not a direct therapeutic drug target[1][7].
- Other names
- MYCL-AS1MYCLos-1
02
Mechanism of action
Not applicable; no drugs identified as targeting this lncRNA
03
Biological functions
Regulation of transcription (specifically, MYC-regulated transcription)Cell cycle controlCell proliferationModulation of cell death and cellular senescence
04
Disease associations
Cancer (specifically implicated in various roles in tumorigenesis and cancer cell biology, e.g., colorectal cancer)
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