Mycobacterial Cell Wall Synthesis Enzymes (None)

Mycobacterial cell wall synthesis enzymes are a group of essential proteins involved in the construction and maintenance of the unique, multi-layered cell wall of *Mycobacterium* species, most notably *Mycobacterium tuberculosis* (Mtb). The mycobacterial cell wall is a complex structure that provides shape, rigidity, and protection against environmental stressors and antibiotics. It is composed primarily of three interconnected layers: peptidoglycan, arabinogalactan, and mycolic acids. These enzymes catalyze the biosynthesis and assembly of these key structural components. The essentiality and uniqueness of these enzymes make them prime targets for anti-tubercular chemotherapy. Targeting these enzymes remains central because the mycobacterial cell wall acts as both a physical barrier against antibiotics/immune effectors and as an active participant in immune evasion strategies. Resistance can also arise from mutations within genes encoding these enzymes or their regulators.

Other names

Mycobacterial cell wall biosynthesis enzymesMtb cell wall synthesis enzymes

Inhibition of cell wall synthesis