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Mycobacterial DNA replication machinery

Molecular classification: Multiprotein complex, Enzyme (includes polymerases, helicases, primases), Other (DNA metabolic machinery)

Overview

Other names: Mycobacterial replisomeMycobacterium tuberculosis DNA replication complexMtb DNA replication machinery

Inhibition of β-clamp disrupts processivity of replicative polymerase and blocks both

DNA replicationGenome maintenanceCell cycle progressionDNA repair (overlapping with some components)

Infection (notably tuberculosis)Drug resistance development in bacteria

Griselimycin (targets β-clamp/DnaN)

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