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Target intelligence / Profile preview
Mycobacterial membrane energetics and pH homeostasis system (Mtb Bioenergetics)
- Target
- Mtb Bioenergetics
- Molecular classification
- Enzyme, Transporter, Ion channel, Oxidoreductase, ATP synthase
01
Overview
- Other names
- Mycobacterial energy metabolismOxidative phosphorylation pathwayProton motive force (PMF) machineryElectron transport chain (ETC) targetsAcidic-environment survival factors
02
Mechanism of action
Inhibition of ATP synthase (Bedaquiline); Inhibition of the Cytochrome bc1:aa3 supercomplex (Telacebec); Disruption of membrane potential and pH gradient (Pyrazinamide/Pyrazinoic acid); Competition for electrons in the respiratory chain (Clofazimine); Dissipation of the proton motive force (Verapamil).
03
Biological functions
ATP synthesisMaintenance of proton motive forcepH homeostasisElectron transportMembrane potential generationNutrient transport
04
Disease associations
Infection
05
Safety considerations
Hepatotoxicity (associated with Pyrazinamide)QT interval prolongation (associated with Bedaquiline and Clofazimine)Hyperuricemia (associated with Pyrazinamide)Drug-drug interactions via CYP3A4 (Bedaquiline)Skin discoloration (Clofazimine)
06
Interacting drugs
Pyrazinamide
6 more in the full profile.
07
Biomarkers
Intrabacterial pHATP levelsMembrane potential (Δψ)Sputum culture conversionpncA mutation status (for Pyrazinamide resistance)
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