Target intelligence / Profile preview

Mycobacterial membrane protein Large 3 (MmpL3)

Target: MmpL3
Molecular classification: Transporter, RND superfamily member

Overview

Mycobacterial membrane protein Large 3 (MmpL3) is an essential transmembrane transporter found in mycobacteria, including *Mycobacterium tuberculosis*. It plays a critical role in the transport of trehalose monomycolate (TMM), a key precursor for the biosynthesis of mycolic acids and complex cell wall lipids. Inhibition of MmpL3 is a validated anti-tuberculosis drug discovery strategy.

Mechanism of action

Inhibition of TMM transport

Biological functions

Lipid transportCell wall biosynthesisTrehalose monomycolate (TMM) transport

Disease associations

InfectionTuberculosis

Safety considerations

Potential for off-target effectsDevelopment of resistance

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